徐磊

一、基本信息

徐磊，男，博士，副教授，博士研究生导师。

2005-2010年就读于吉林大学动物医学专业（五年制），获农学学士学位

2010-2013年就读于西北农林科技大学预防兽医学专业，获农学硕士学位

2013-2017年就读于荷兰鹿特丹伊拉斯姆斯大学（Erasmus University Rotterdam），获博士学位

2017年至今，于西北农林科技大学生命科学学院从事教学科研工作。

二、研究方向

微生物-宿主（天然免疫）相互作用机制

微生物生理生化与环境适应机制

研究生招生专业：环境微生物

三、开设课程

承担本科生《微生物学》、《微生物学实验》、研究生《微生物学进展》等课程的教学工作。

四、科研项目

1）国家自然科学基金面上项目，54万元，主持；2023.01-2026.12

2）国家自然科学基金青年项目，28万元，主持（结题）；2019.01-2021.12

3）中国博士后科学基金特别资助项目，18万元，主持（结题）；2020.06-2021.12

4）陕西博士后科学基金特别资助项目，15万元，主持（结题）；2018.12-2020.06

5）中国博士后科学基金面上资助项目，8万元，主持（结题）；2018.03-2019.12

6）陕西省自然科学基础研究计划，3万元，主持（结题）；2020.01-2021.12

7）西北农林科技大学博士科研启动基，20万元，主持（结题）；2018.03-2020.12

五、主要相关论著

1. Song L(#), Xu L(#), Wu T(#), Shi Z, Kareem HA, Wang Z, Dai Q, Guo C, Pan J, Yang M, Wei X, Wang Y, Wei G(*), Shen X(*). Trojan horselike T6SS effector TepC mediates both interference competition and exploitative competition. ISME J. 2024 Jan 8;18(1):wrad028.

2. Xie Z(#), Wang X(#), Huang Y(#), Chen S, Liu M, Zhang F, Li M, Wang X, Gu Y, Yang Y, Shen X, Wang Y(*), Xu Y(*), Xu L(*). Pseudomonas aeruginosa outer membrane vesicle-packed sRNAs can enter host cells and regulate innate immune responses. Microb Pathog. 2024 Mar;188:106562.

3. Tang J(#), Gu Y(#), Wang X, Luo Y, Zhang F, Zheng J, Wang Y, Shen X(*), Xu L(*). Salmonella T3SS-elicited inflammatory innate immune response inhibits type I IFN response in macrophages. Vet Microbiol. 2024 Feb;289:109970. 

4. Xu L, Shen X(*). Bacterial communication mediated by T4SS effectors. Phytopathol Res. 2023 5:56. 

5. Wang X(#), Tang J(#), Dang W(#), Xie Z, Zhang F, Hao X, Sun S, Liu X, Luo Y, Li M, Gu Y, Wang Y, Chen Q(*), Shen X(*), Xu L(*). Isolation and Characterization of Three Pseudomonas aeruginosa Viruses with Therapeutic Potential. Microbiol Spectr. 2023 Jun 15;11(3):e0463622.

6. Gu Y(#), Tang J(#), Zhang F, Qu Y, Zhao M, Li M, Xie Z, Wang X, Song L, Jiang Z, Wang Y(*), Shen X(*), Xu L(*). Manganese potentiates lipopolysaccharide-induced innate immune responses and septic shock. Int J Biol Macromol. 2023 Mar 1;230:123202. 

7. Xu L(#), Li M(#), Yang Y(#), Zhang C, Xie Z, Tang J, Shi Z, Chen S, Li G, Gu Y, Wang X, Zhang F, Wang Y, Shen X(*). Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release. mBio. 2022 Jun 28;13(3):e0363221.

8. Zhu L(#), Xu L(#), Wang C(#), Li C, Li M, Liu Q, Wang X, Yang W, Pan D, Hu L, Yang Y, Lu Z, Wang Y, Zhou D(*), Jiang Z(*), Shen X(*). T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2103526118.

9. Lin J(#), Xu L(#), Yang J, Wang Z, Shen X(*). Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance. Stress Biol. 2021 Nov 3;1(1):11. 

10. Li N, Liu J, Qi J, Hao F, Xu L(*), Guo K(*). Genetic Diversity and Prevalence of Porcine Circovirus Type 2 in China During 2000-2019. Front Vet Sci. 2021 Dec 15;8:788172. 

11. Guo K(#), Zhang X(#), Hou Y(#), Liu J, Feng Q, Wang K, Xu L(*), Zhang Y(*). A novel PCV2 ORF5-interacting host factor YWHAB inhibits virus replication and alleviates PCV2-induced cellular response. Vet Microbiol. 2020 Dec;251:108893. 

12. Ouyang Y(#), Xu L(#), Lv J, Hou Y, Fan Z, Xu P, Jiang Y, Wu M, Li R, Zhang Y, Guo K(*). Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages. Arch Virol. 2019 May;164(5):1323-1334. 

13. Zheng H(#), Xu L(#), Liu Y, Li C, Zhang L, Wang T, Zhao D, Xu X(*), Zhang Y(*). MicroRNA-221-5p Inhibits Porcine Epidemic Diarrhea Virus Replication by Targeting Genomic Viral RNA and Activating the NF-κB Pathway. Int J Mol Sci. 2018 Oct 29;19(11):3381.

14. Guo K(#), Xu L(#), Wu M, Hou Y, Jiang Y, Lv J, Xu P, Fan Z, Zhang R, Xing F(*), Zhang Y(*). A Host Factor GPNMB Restricts Porcine Circovirus Type 2 (PCV2) Replication and Interacts With PCV2 ORF5 Protein. Front Microbiol. 2019 Jan 8;9:3295.

15. Dai Q(#), Xu L(#), Xiao L, Zhu K, Song Y, Li C, Zhu L, Shen X(*), Wang Y(*). RovM and CsrA Negatively Regulate Urease Expression in Yersinia pseudotuberculosis. Front Microbiol. 2018 Feb 27;9:348. 

16. Xu L, Wang W, Peppelenbosch MP, Pan Q(*). Noncanonical Antiviral Mechanisms of ISGs: Dispensability of Inducible Interferons. Trends Immunol. 2017 Jan;38(1):1-2.

17. Xu L, Wang W, Li Y, Zhou X, Yin Y, Wang Y, de Man RA, van der Laan LJW, Huang F, Kamar N, Peppelenbosch MP, Pan Q(*). RIG-I is a key antiviral interferon-stimulated gene against hepatitis E virus regardless of interferon production. Hepatology. 2017 Jun;65(6):1823-1839. 

18. Xu L, Zhou X, Wang W, Wang Y, Yin Y, Laan LJ, Sprengers D, Metselaar HJ, Peppelenbosch MP, Pan Q(*). IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN-stimulated genes. FASEB J. 2016 Oct;30(10):3352-3367. 

19. Xu L, Zhou X, Peppelenbosch MP, Pan Q(*). Inhibition of hepatitis E virus replication by proteasome inhibitor is nonspecific. Arch Virol. 2015 Feb;160(2):435-9. 

六、联系方式

联系地址：陕西杨凌西农路22号西北农林科技大学生命科学学院

邮编：712100

Email: xulei@nwafu.edu.cn